People

Group leader

Roman Tuma

principal investigator
Virus assembly and molecular machines
Lab responsibilities: HPLC, solution scattering techniques
rtuma at prf.jcu.cz
(+420)-38-777-6235
C 01 026
Visiting at University of Leeds, U.K.

Research interests

1. Virus assembly – dsRNA viruses/Avian reovirus, viral factories/viroplasms

2. Mechano-chemical coupling in molecular motors that translocate along nucleic acids and polypeptides e.g. viral ATPases and SecYEG/SecA

3. Assembly of bacteriochlorophylls and structure of light harvesting antennae – chlorosomes

4. Ligand activated transcription factors – Juvenile Hormone Receptor structure and dynamics

We apply combination of advanced biophysical and structural techniques to study self-assembly and function of large macromolecular complexes such as viruses, Sec translocon, helicases and light harvesting complexes. Key biological processes that are studied in our group: RNA packaging and segment assortment in dsRNA viruses of the Reoviridae family; mechanism and dynamics of hexameric helicases and SecA driven polypeptide translocation across membranes. We also use self-assembly of bacterial photosynthetic pigments to create hybrid quantum dot nanostructures for applications in synthetic biology and nanophotonics.

Project manager

Renata Krinesová

project manager
rkrinesova at prf.jcu.cz
(+420)-38-777-5576
Project Department, ÚMBR BC AV, 3rd floor

Researchers

Filip Dyčka

Reasearch interests: proteomics, MS
Facility responsibility: Mass Spectrometry
fdycka at prf.jcu.cz
(+420)-38-777-6242
C 01 044

Tomáš Fessl

single-molecule fluorescence
fessl at prf.jcu.cz
(+420)-38-777-6238
C 01 038

Zdeněk Franta

molecular biology
zfranta at prf.jcu.cz
(+420)-38-777-6230
C 01 019

Zdeno Gardian

Cryo-EM
gardian at prf.jcu.cz
(+420)-38-777-5459
Laboratory of EM
Part time also at Institute of parasitology BC, ASCR

David Kaftan

Research interests: photosynthesis, spectroscopy, AFM
Facility responsibility: AFM
dkaftan at prf.jcu.cz
(+420)-38-777-6227
C 01 016
Part time also at Institute of Microbiology ASCR